A method for controlling the affinity of an antibody for an antigen, an antibody having a modified affinity for an antigen, and a method for producing the same.

摘要

PROBLEM TO BE SOLVED: To provide a technique for controlling an affinity for an antibody of an antibody and an antibody having a modified affinity for the antigen. Depending on the electrical properties of the CDRs based on the amino acid sequences of the complementarity determining regions (CDRs), at least three amino acid residues in the framework region 3 defined by the Chothia method in an antibody may be charged amino acid residues. By substituting with, the above problem is solved. [Selection diagram] None