SCLERAL LIPID METABOLIC PATHWAY INTERVENTION REGULATOR OR APPLICATION OF LIPID METABOLISM REGULATING DRUG AS DRUG FOR INHIBITING MYOPIA AMETROPIA AND AXIS OCULI EXTENSION

摘要

A scleral lipid metabolic pathway intervention regulator or an application of a lipid metabolism regulating drug as a drug for inhibiting myopia ametropia and axis oculi extension. By means of a myopia mouse RNA-seq experiment, it is discovered that a scleral lipid metabolic pathway is significantly reduced, and the gene expression of a plurality of key enzymes in the lipid metabolic pathway is reduced. By means of a myopia sclera electron microscope, lipid droplet deposition is observed and discovered, which further indicates that the lipid metabolism in myopia sclera is abnormal, and the scleral lipid metabolism is regulated by means of ω-3, so that myopia ametropia and axis oculi extension can be effectively inhibited.