Use of DRG2 gene as dopamine release modulator

摘要

The present invention relates to the use of the DRG2 gene as a dopamine release regulator, and more particularly, a method for providing information for diagnosing a dopaminergic dysfunction disease using the DRG2 gene; a method for screening a candidate for preventing or treating a dopaminergic dysfunction disease; DRG2 gene knockout (Knock-out) dopamine dysfunction disease animal model; And it relates to a screening method for a candidate substance for preventing or treating a dopaminergic dysfunction disease using the animal model. The present invention was the first to investigate the use of the DRG2 gene as a modulator of dopamine release from dopaminergic neurons in the brain as a novel function. Therefore, it is possible to diagnose various diseases (motor disorders, depression, emotional disorders, Parkinson's disease, etc.) related to dopaminergic action by confirming the deficiency, abnormal expression or dysfunction of DRG2. In addition, in the case of an animal in which the DRG2 gene is knocked out, it may be usefully used as an animal model for a dopaminergic dysfunction disease.