RECOMBINANT ANTIBODY OF ANTI-HUMAN N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE

摘要

The present disclosure relates to a novel isolated binding protein including a N-terminal pro-brain natriuretic peptide (NT-proBNP) antigen binding domain, and the preparation method therefor. The antigen-binding domain includes at least one complementarity determining region selected from the amino acid sequences as defined in the present disclosure: or; has at least 80% sequence identity with the complementarity determining region of the following amino acid sequence and has an affinity of KD≤2.26×10−8 to NT-proBNP. The binding protein may be used in the detection field of NT-proBNP protein.