METHODS FOR PREDICTING THE OUTCOME OF PATIENTS HAVING ACUTE ISCHEMIC STROKE

摘要

Accumulating evidence point to a major role of neutrophils in the pathophysiology of acute ischemic stroke (AIS). Whether and how neutrophil activation evolves following endovascular therapy (EVT) for AIS remains unknown. Here, the inventors investigated correlations between dynamic changes in plasma levels of neutrophil activation markers and AIS outcome in EVT-treated patients. Plasma levels of matrix metalloproteinase-9 (MMP-9), neutrophil elastase (NE), MPO, and citrullinated histone H3 (H3Cit) were measured at admission and at 1h and 24h post-EVT. The results show that plasma levels of MMP-9, MPO and H3Cit continue evolving after successful recanalization by EVT, with an early and transient increase in MPO and H3Cit plasma levels at 1 h post-EVT, and a gradual decrease in MMP-9 plasma level. Higher admission levels of H3Cit were also associated with poor functional outcome. In conclusion, the results show that admission H3Cit level are associated with outcome in AIS patients, and support the notion that neutrophil effectors are informative biomarkers of AIS severity and prognosis.