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Orally dissolving melatonin formulation with acidifying agent that renders melatonin soluble in saliva
Orally dissolving melatonin formulation with acidifying agent that renders melatonin soluble in saliva
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机译:用酸化剂口服溶解褪黑激素制剂,使褪黑素可溶于唾液中的褪黑素
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摘要
A composition includes a pharmaceutical dosage form configured to disintegrate in oral saliva and maintain a pH of 4 or less within the saliva during the time the dosage form is dissolving therein, the dosage form including a therapeutically effective amount of melatonin in a polymer carrier matrix and a sufficient amount of acid to impart the pH to the saliva, the amount of disintegrant being sufficient to cause the dosage form to completely disintegrate in the saliva within ten minutes from contacting the saliva.
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