? ? ?PNEUMOCYSTIS? ? ? ? ?TRITERPENOID ANTIFUNGALS FOR THE TREATMENT OR PREVENTION OFSPP. PNEUMONIA

摘要

Enfumafungin derivative triterpenoid antifungal compounds are used to treat and/or prevent Pneumocystis pneumonia (PCP) due to their unexpected efficacy against Pneumocystis spp. including their ability to reduce the lung burden of cyst and trophic forms of this fungi. The enfumafungin derivative triterpenoids (or pharmaceutically acceptable salts or hydrates thereof) are inhibitors of (1,3)-β-D-glucan synthesis and are useful in the treatment and/or prevention of PCP since they demonstrate potent activity against Pneumocystis spp. in in vivo models, exhibit adequate tissue penetration into lungs, and are well tolerated.