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IMPROVED ALIGNMENT USING HOMOPOLYMER-COLLAPSED SEQUENCING READS
IMPROVED ALIGNMENT USING HOMOPOLYMER-COLLAPSED SEQUENCING READS
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机译:使用均聚物折叠测序改善对准读数
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摘要
The present disclosure provides, inter alia, methods, compositions, and computer implemented processes for resolving long and highly similar, but non-identical, genomic regions to improve assembly quality, especially for polyploid genomes. Aspects of the disclosure are draw to using exact string matching of homopolymer-collapsed sequence reads to determine whether two sequences overlap and thus represent the same genomic region (e.g., the same haplotype in polyploid genomes) or whether the sequences represent different genomic regions.
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