Bispecific HIV-1 neutralizing antibody

摘要

To provide a bispecific HIV-1 neutralizing antibody.SOLUTION: In various embodiments, the present invention generally relates to using a bispecific antibody for preventing and treating HIV. In one aspect, the present invention relates to a bispecific antibody for neutralizing HIV. This bispecific antibody includes an area of first and second antibodies, and the first antibody binds to HIV envelope protein. In a specific embodiment, the first antibody is selected from PGT145, PG9, PGT128, PGT121, 10-1074, 3BNC117, VRC01, PGT151, 4E10, 10E8 and a variant thereof. In a specific embodiment, this bispecific antibody includes an area of the second antibody, and the second antibody binds to cell membrane protein.SELECTED DRAWING: None