TREATMENT METHOD OF LEFT VENTRICULAR DYSFUNCTION FOLLOWING AN ACUTE MYOCARDIAL INFARCTION

摘要

The present invention refers to a composition comprising a compound capable of reducing the expression of the Yin Yang-1 (Yy1) gene in cardiac cells of a human or animal subject with respect to the expression observed in the absence of the compound in said cells, wherein the compound is a RNA interference (RNAi) of the Yy1 gene, and wherein said composition is for use in a method of treatment of left ventricular (LV) dysfunction following myocardial infarction (AMI) in the subject, and wherein said composition is administered between 12 hours and 7 days after the onset of myocardial infarction (AMI) in the subject.