首页>
外国专利>
Istaroxime-containing intravenous formulation for the treatment of acute heart failure (AHF)
Istaroxime-containing intravenous formulation for the treatment of acute heart failure (AHF)
展开▼
机译:含Istaroxime的静脉注射配方,用于治疗急性心力衰竭(AHF)
展开▼
页面导航
摘要
著录项
相似文献
摘要
Compositions for intravenous infusion of istaroxime, or a metabolite of istaroxime, in human patients suffering from heart failure are disclosed. Likewise, methods for extended infusion of istaroxime or its metabolites in individuals with heart failure are disclosed. In particular, some methods disclosed herein include the infusion of istaroxime, or a metabolite thereof, for a period of time that is greater than six hours in order to improve cardiac relaxation without triggering arrhythmogenic events in an individual suffering from heart failure. Other methods include administration of istaroxime until certain plasma concentration thresholds of istaroxime metabolites are achieved. Also disclosed are istaroxime metabolites with selective SERCA2a activation.
展开▼