PD-L1 PD-1 PD-1 VARIANTS WITH INCREASED BINDING TO PD-L1

摘要

The present invention relates to a PD-1 mutant having increased binding affinity to PD-L1 and aglycosylation characteristic, and the PD-1 mutant of the present invention has significantly increased PD-L1 and Because it has binding power and is a glycosylated mutant, but has improved binding power and stability, it is possible to simultaneously overcome the problem of low binding force of conventional PD-1 to PD-L1 and the problem of glycan heterogenity of protein therapeutics. It is inexpensive and easy to mass-produce, and there is an effect that it is possible to manufacture biopharmaceuticals without problems due to cell lines, culture processes, and purification processes.