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Assessment of JAK-STAT1 / 2 cell signaling pathway activity using mathematical modeling of target gene expression
Assessment of JAK-STAT1 / 2 cell signaling pathway activity using mathematical modeling of target gene expression
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机译:使用靶基因表达数学建模评估JAK-STAT1 / 2细胞信号传导途径活性
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摘要
The present invention relates to a computer-implemented method for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject based on expression levels of three or more target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the JAK-STAT1/2 cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject, and to the use of such kits in performing the method.
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