- ANTIBODY RECOGNIZING HUMAN LEUKEMIA INHIBITORY FACTOR LIF AND USE OF ANTI-LIF ANTIBODIES IN THE TREATMENT OF DISEASES ASSOCIATED WITH UNWANTED CELL PROLIFERATION

摘要

The present invention relates to antibodies directed against human leukemia inhibitory factor (LIF), and to hybridoma cell lines producing such antibodies. The present invention also provides methods of blocking/inhibiting proliferation of stem cells, and diagnosing a disease associated with unwanted cell proliferation in a subject, or determining a predisposition of a subject to suffer from a disease associated with said unwanted cell proliferation, or said disease An in vitro method of prognosing the mean life expectancy of a subject suffering from The therapeutic potential of these antibodies is based on the observation that LIF inhibition can be used in therapeutic compositions for the treatment of diseases associated with unwanted cell proliferation.