ROLLER COMPACTOR AND METHOD OF DRY GRANULATION USING A ROLLER COMPACTOR

摘要

A continuous method of producing granules comprising a salt of N-(8-(2- hydroxybenzoyl)amino)caprylic acid or SNAC. The method comprises: (i) providing a powder comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid, (ii) dry granulating the powder by using a roller compactor, (iii) continuously during dry granulation removing material accumulating on roller rims and leading the material towards the outlet. The roller compactor comprises a pair of pressing rollers 212 comprising a first 212a and a second pressing roller 212b, and wherein the first pressing roller 212a comprises roller rims 213. The roller compactor may further comprise a granulator 216, a sieve 218, and an exit chute 203 mounted below the sieve 218. The roller compactor further comprises roller rim strippers 250 for removing material accumulating on the roller rims 213. The roller compactor can further comprise an agitator adapted for agitating product tending to accumulate or build-up below the sieve insert 218.