Oral administration of diltiazem

摘要

Problem to be solved: to provide an intranasal dosage form capable of injecting immediately containing a stabilized aqueous solution of diltiazem useful as a calcium ion inflow inhibitor (delayed channel blocker or calcium channel blocker).A. (a) diltiazem or its pharmaceutically acceptable salt(b) pH adjustments to reduce the pH range from 3 toAnd (c) ethanolAn implantable stable aqueous solution comprisingAndInjection vessel filled with the aqueous solutionIncludingWhereThe aqueous solution at least 6 months at room temperatureOr at least 6 months at 2 to 8Or both.AndHaving deacetylzirthiazem impurities less than 2%AndDosage form is due to parenteral administration.It is assumed to be the parenteral dosage form.No selection