A filtration device is provided that includes porous polyparaxylylene (PPX) filtration articles.The PPX filtration article comprises at least one PPX polymer membrane layer and one or more substrates.In some cases, the PPX filtration article may include one or more support layers.The PPX polymer film has a pore size of about 1 nm to about 100 nm.The filtered article has PVA 20 and / or less than about 30 g / m2 of mass / area (MPA) less than about 0.6 cm3 / m2.The PPX filtration article isolates and holds nanoparticles from a highly permeable supply fluid.In use, the PPX filtration article fills nanoparticles from the feed stream by passing the supply fluid through at least one PPX polymer membrane in the filtered article separated and removed from the feed fluid.The PPX polymer film can be resistant to chemical attack, gamma ray, thermally stable, biocompatible and strong.
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