METHOD FOR THE PREPARATION OF DEUTERATED OR TRITIATED COMPOUNDS

摘要

Provided is a method for the preparation of a deuterated or tritiated aromatic compound via deuteration or tritiation of an aromatic starting compound which comprises an aromatic ring or a fused aromatic ring system which may be carbocyclic or hetercyclic and which carries at least one hydrogen atom directly bonded to a carbon ring atom of an aromatic ring, said method comprising:a) providing a liquid composition wherein the aromatic starting compound is dissolved or dispersed in a deuterated or tritiated solvent which is not water, or in a solvent system comprising at least one deuterated or tritiated solvent which is not water; andb) replacing at least one hydrogen atom directly bonded to a carbon ring atom of an aromatic ring comprised by the aromatic starting compound with deuterium or tritium via the transfer of at least one deuterium of tritium atom from the deuterated or tritiated solvent to the aromatic starting compound dissolved or dispersed in the liquid composition in the presence of an acid,to convert the aromatic starting compound to a deuterated or tritiated aromatic compound which comprises an aromatic ring or a fused aromatic ring system which may be carbocyclic or hetercyclic and which carries at least one deuterium or tritium atom directly bonded to a carbon ring atom of an aromatic ring.