SELECTIVE AND REVERSIBLE BREAKING OF THE BLOOD-BRAIN BARRIER BY ULTRASOUND EMISSION

摘要

The present invention relates to an ultrasound emitting device (1), configured to selectively and reversibly break the blood-brain barrier of a patient, comprising a structure (2) configured to be placed on at least one portion of the head of the patient, at least two ultrasound transducers (3) coupled to the structure (2) and configured to emit ultrasounds of diagnostic intensity. The present invention also relates to a method for improving the bioavailability in brain tissue of at least one inflammation mediator in a patient. The present invention also relates to a method for treating diseases of the central nervous system using the method of the present invention to improve the bioavailability of inflammation mediators in a patient in need of same. The present invention also relates to a method for treating diseases of the central nervous system using the device of the present invention. Finally, the invention relates to the use of the present device for the treatment of diseases of the central nervous system.