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LATERAL FLOW ASSAY DEVICE FOR TRAUMATIC BRAIN INJURY DIAGNOSIS USING TIME-RESOLVED FLUORESCENCE ANALYSIS, AND METHOD FOR DIAGNOSING TRAUMATIC BRAIN INJURY BY USING SAME
LATERAL FLOW ASSAY DEVICE FOR TRAUMATIC BRAIN INJURY DIAGNOSIS USING TIME-RESOLVED FLUORESCENCE ANALYSIS, AND METHOD FOR DIAGNOSING TRAUMATIC BRAIN INJURY BY USING SAME
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机译:用于创伤性脑损伤的侧向流动测定装置使用时间分辨荧光分析,以及使用该方法诊断创伤性脑损伤的方法
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摘要
A lateral flow assay device for detecting a traumatic brain injury marker according to an embodiment of the present invention comprises: a sample pad into which a blood sample containing a traumatic brain injury marker is injected; an adsorption pad comprising a probe which is mixed with the marker when the traumatic brain injury marker migrates from the sample pad, to form a traumatic brain injury marker complex; and a porous membrane which is in fluid communication with the adsorption pad and allows capillary movement of the traumatic brain injury marker complex from the adsorption pad to a detection line, wherein the probe comprises: capture antibodies consisting of antibodies labeled with a specific binding material that specifically binds to the traumatic brain injury marker; and detector antibodies consisting of antibodies labeled with a fluorescent material with a relatively long emission lifetime of 1 microsecond or greater, and, as the antibodies labeled with a specific binding material or a fluorescent material, a mixture of antibodies derived from at least two different species is used.
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