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Materials and methods for directing carbon flux and increased production of 7-aminoheptanoic acid or 6-aminohexanoic acid
Materials and methods for directing carbon flux and increased production of 7-aminoheptanoic acid or 6-aminohexanoic acid
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机译:用于引导碳通量的材料和方法,增加7-氨基庚酸或6-氨基己酸的产量增加
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摘要
This disclosure relates to genome-scale attenuation or knockout strategies for directing carbon flux to certain carbon based building blocks within the 7-aminoheptanoic acid (7-AHA) and 6-aminohexanoic acid (6-AHA) biosynthesis pathways, for example, to achieve reduced flux to unwanted side products while achieving increased production of desired intermediates and end products. This disclosure also relates to non-naturally occurring mutant bacterial strains comprising one or more gene disruptions in aldehyde reductase and/or aldehyde dehydrogenase genes that are generated to direct carbon flux to certain carbon based building blocks. This disclosure further relates to a method for enhancing production of carbon based building blocks by generating non-naturally occurring mutant bacterial strains, culturing said mutant bacterial strains in the presence of suitable substrates or under desired growth conditions, and substantially purifying the desired end product.
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