Composition and method for enhancing targeted cell killing by NK cells

摘要

The present disclosure provides immunotherapeutic compositions and methods for enhancing the immune response in the subject and treating cancer or inflammatory conditions mediated by autoreactive B cells.In some embodiments, a multiplex specific antigen binding construct that recognizes at least one tumor antigen or B series cell antigen and NKp30 and / or another activated NK receptor is provided.In some embodiments, a multiplex specific antigen binding construct that recognizes two antigens, NKp30, and another activated NK receptor expressed by at least two tumor antigens or B lineage cells is provided.Although multiple specific antigen binding constructs and methods disclosed herein are characterized by CD16 deficient microenvironments and / or cancer cells characterized by target cells (e.g., cancer cells) having low levels of tumor antigen expression Can be used for cancer treatment.