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ENVELOPE VIRUS RESISTANT TO INACTIVATION WITH COMPLETE FOR TREATMENT OF MALIGNANT TUMORS
ENVELOPE VIRUS RESISTANT TO INACTIVATION WITH COMPLETE FOR TREATMENT OF MALIGNANT TUMORS
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机译:具有抗动性的包络病毒与完全用于治疗恶性肿瘤的灭活
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摘要
A recombinant fusion protein is disclosed. The fusion protein comprises: (a) a CD55 peptide sequence, (b) a linker sequence C-terminal to the CD55 sequence, (c) a transmembrane domain C-terminal to the linker sequence, and (d) an intracellular domain C-terminal to the transmembrane domain. The fusion protein does not contain a GPI anchor. The fusion protein can be expressed with an N-terminal secretory signal peptide, which is cleaved to yield the mature protein on the surface of a cell line or an enveloped virus. An oncolytic virus expressing the fusion protein is resistant to complement inactivation and can be used to treat cancer.
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