POLYGENIC RISK SCORE MODIFIES RISK OF CORONARY ARTERY DISEASE CONFERRED BY LOW-DENSITY LIPOPROTEIN CHOLESTEROL

摘要

A method for a predictive prognosis of onset of a cardiovascular disease in an individual acquires/accesses low-density lipoprotein cholesterol level, calculating a risk value and determining an individualized risk value of onset of the cardiovascular disease, based on the calculated risk value. Calculating a risk value includes calculating the risk value representative for onset of the cardiovascular disease, based on operational values of a polygenic risk score and low-density lipoprotein cholesterol level, based on first, second and third risk parameters are representative of risk of onset of: the cardiovascular disease induced by the polygenic risk score, the cardiovascular disease induced by the low-density lipoprotein cholesterol level, and the cardiovascular disease induced by interaction of polygenic risk score and low-density lipoprotein cholesterol level. The risk parameters are calculated based on a pre-trained model and/or algorithm, to which the operational values of polygenic risk score and low-density lipoprotein cholesterol level are input.