DESIGN SYNTHESIS AND METHODS OF USE OF ACYCLIC FLEXIMER NUCLEOSIDE ANALOGUES HAVING ANTI-CORONAVIRUS ACTIVITY

摘要

The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.