BIOMARKERS FOR PRECISELY PREDICTING THE GLOMERULAR FILTRATION RATE AND FOR INDICATING PATHOPHYSIOLOGIC FACTORS OF AN IMPAIRED GLOMERULAR FILTRATION RATE

摘要

An aspects of the invention relates to the use of a marker set comprising at least three substances chosen from the group consisting of alanine, choline, creatine, creatinine, dimethyl sulfone, dimethylamine, glucose, glycerol, isoleucine, leucine, myo-inositol, N,N-dimethylglycine, and valine in an in vitro method for calculating a glomerular filtration rate of an individual and/or in an in vitro method for providing an indicator of a pathophysiologic factor of an impaired glomerular filtration rate. Another aspect of the invention relates to a method for calculating a glomerular filtration rate of an individual based on such a marker set.