A method for quantitatively analyzing module changes in biomolecular networks before and after drug intervention

摘要

This is a quantitative analysis method used to quantitatively compare the degree of change in the modules of the biomolecular network before and after drug intervention. This method integrates the phase parameters of modules with different dimensions (attributes), builds and quantifies a comprehensive and comprehensive indicator of module changes, and module of biomolecular network before and after drug intervention The degree of change is quantitatively analyzed and compared. The method includes 1) building a biomolecule network before drug intervention and a biomolecule network after drug intervention, identifying a module of biomolecule network before drug intervention and a module of biomolecule network after drug intervention; 2) Collating modules of biomolecular networks before and after drug intervention showing change, identifying pairs of modules showing change, and 3) showing different dimensions of the module Integrating phase parameters, combining phase parameter weights, building a comprehensive module evaluation system, calculating the overall conformational change of modules in biomolecular networks before and after drug intervention; including. The present invention can be applied to fields such as bionetwork analysis, new drug design and development, and pharmacological mechanism research. [Selection] Figure 8