D Platycodin D Composition for the prevention and treatment of hypercholesterolemia in combination comprising extract of Platycodon grandiflorum or Platicodin D from Platycodon grandiflorum

摘要

The present invention is Gilgyeong extract or Platycodin D (Platycodin D) derived therefrom; And, comprising a statin-based drug as an active ingredient, a pharmaceutical composition for the prevention or treatment of hypercholesterolemia, an anti-hypercholesterolemia adjuvant, a gilkyung extract comprising a gilkyung extract or platicodin D derived therefrom as an active ingredient or platicodin D derived therefrom; And a kit for preventing or treating hypercholesterolemia, including a statin-based drug as an active ingredient, gilkyong extract or platicodin D derived therefrom; And a method for preventing or treating hypercholesterolemia, comprising administering a statin-based agent in combination to an individual other than a human, containing gilkyung extract or platicodin D derived therefrom as an active ingredient, hypercholesterolemia treatment or It relates to a method for increasing low-density lipoprotein receptor expression, comprising the step of treating liver cells in vitro with a prophylactic composition, gilgyeong extract or platicodin D derived therefrom. Gilgyeong extract of the present invention or Platicodin D contained therein is administered in combination with a conventional hypercholesterolemia treatment chemical, and is a novel molecular mechanism that induces hepatocyte low-density lipoprotein receptor (LDLR) expression, effectively preventing or treating hypercholesterolemia. can