A new pathway for the synthesis of tufamidis and new polymorphs

摘要

The present invention relates to a new route for synthesizing crystalline tufamidis polymorphs starting from a tufamidacetic acid adduct.AndThe present invention relates toTufamizis (2 - (3)5 - dichlorophenyl3 - benzoxazole-6 - carboxylic acid * (2R)3R,4R,5S) - 6 - (methyl amino) - hexan-12345 - pentol)The process of synthesizing a new tufamium crystalline polymorphThe present invention relates to therapeutic compositions comprising novel crystalline polymorphs and therapeutic use of such new polymorphs.