首页> 外国专利> MECHANISTIC BACTERIAL EFECTOR TO PREVENT APOPTOSIS OF HUMAN BETA CELLS

MECHANISTIC BACTERIAL EFECTOR TO PREVENT APOPTOSIS OF HUMAN BETA CELLS

机译：机械细菌效应，以防止人β细胞的凋亡

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摘要

A composition is provided herein, including microvesicles (MVs) isolated from a naturally occurring probiotic Lactobacillus sp. wherein the MVs are packaged in a capsule, emulsion, or tablet such that the packaged MVs are protected in a gastrointestinal tract for transport to an intestine of a subject. In another embodiment, a method for treating Type-1 diabetes including orally administering to a diabetic or pre-diabetic subject, or a subject at risk for becoming pre-diabetic or diabetic, a composition comprising an effective amount of microvesicles isolated from a naturally occurring probiotic strain comprising a Lactobacillus sp.i. In still a further embodiment, of improving immune function in a subject, comprising administering to the subject, the composition comprising an effective amount of microvesicles isolated from a naturally occurring probiotic Lactobacillus sp.

机译：本文提供了一种组合物，包括从天然存在的益生菌乳酸杆菌中分离的微泡（MV）。其中MV包装在胶囊，乳液或片中，使得包装的MV在胃肠道中受到保护，用于运输给受试者的肠道。在另一个实施方案中，一种用于治疗1型糖尿病的方法，包括口服给糖尿病或糖尿病患者或患有预糖尿病患者或糖尿病患者的受试者，该组合物包含有效量的自然发生的微绒毛粒子益生菌菌株包含乳杆菌/ sp.i。在又一个实施方案中，在将受试者中改善免疫功能，包括向受试者施用，该组合物包含从天然存在的益生菌乳杆菌中分离的有效量的微泡来分离的微泡。 展开▼

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公开/公告号US2021205379A1

专利类型

公开/公告日2021-07-08

原文格式PDF

申请/专利权人 UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED;
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申请/专利号US201917059586

发明设计人 GRACIELA LILIANA LORCA;CLAUDIO F. GONZALEZ;
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申请日2019-05-30

分类号A61K35/747;A61P3/10;

国家 US

入库时间 2022-08-24 19:46:57

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1. BCL-2蛋白表达剂、细胞凋亡抑制剂和表皮细胞的紫外线DNA损伤防止剂 [P] . 中国专利： CN102036674B . 2013.07.31

2. BCL-2蛋白表达剂、细胞凋亡抑制剂和表皮细胞的紫外线DNA损伤防止剂 [P] . 中国专利： CN102036674A . 2011-04-27

3. MECHANISTIC BACTERIAL EFECTOR TO PREVENT APOPTOSIS OF HUMAN BETA CELLS [P] . 世界知识产权组织专利： WO2019232122A1 . 2019-12-05

机译：预防人类BETA细胞凋亡的机械细菌因子

4. use of bacterial strains of a lactic acid to prevent or treat a tumor, composition for treating or preventing cancer, method for facilitating apoptosis of cancer cells in a mammal, kit for preventing or treating cancer in a mammal, and foodstuffs for antitumor. [P] . BR112012021624A2 . 2017-02-07

机译：乳酸菌菌株用于预防或治疗肿瘤的用途，用于治疗或预防癌症的组合物，在哺乳动物中促进癌细胞凋亡的方法，用于预防或治疗哺乳动物中的癌症的试剂盒以及用于抗肿瘤的食品。

5. chimeric antibody or fragment thereof, or humanized antibody or fragment thereof, nucleic acid molecule, expression vector, cell, composition, methods of preventing, treating or alleviating the effects of one or more diseases, of diagnosing a disease or condition associated with amyloid in an individual, determining the extent of amyloidogenic plaque burden in an individual's tissue and / or body fluids, disaggregating preformed beta-amyloid fibers and preventing abet-induced neuron degradation, test, chain variable region, and cell lineage [P] . BRPI0812478A2 . 2017-05-16

机译：嵌合抗体或其片段，或人源化抗体或其片段，核酸分子，表达载体，细胞，组合物，预防，治疗或减轻一种或多种疾病的影响，诊断与淀粉样蛋白有关的疾病或病症的方法个体，确定个体组织和/或体液中淀粉样蛋白斑块负担的程度，分解预先形成的β-淀粉样蛋白纤维并防止教bet诱发的神经元降解，测试，链可变区和细胞谱系

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5. Preventing Cell Death and Dysfunction for Human-sourced Beta Cells via Oxygen-generating Disk [C] . Jia-Pu Liang, Maria Coronel, Cherie Stabler Society for Biomaterials annual meeting and exposition . 2019

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8. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). 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V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

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