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A REAL-TIME, ADD-AND-READ FLUORESCENCE-BASED ASSAY FOR TESTING FUNCTION AND DRUG INTERACTIONS OF OATP TRANSPORTERS
A REAL-TIME, ADD-AND-READ FLUORESCENCE-BASED ASSAY FOR TESTING FUNCTION AND DRUG INTERACTIONS OF OATP TRANSPORTERS
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机译:用于测试功能和oATP运输机的药物相互作用的实时,添加和读取荧光的测定
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摘要
The invention relates to the field of assessing transport activity of OATP (Organic anion-transporting polypeptide) transport proteins. In particular, the invention relates to a real-time, add-and-read fluorescence-based method for determining whether a test compound interferes with substrate transport activity of an OATP, by using a non-fluorescent control substrate which becomes fluorescent within a cell. The method is also applicable to measure the expression of an OATP and to discriminate between a transported substrate and an inhibitor of an OATP.
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