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EXOGENOUS GENE EXPRESSION IN THERAPEUTIC ADENOVIRUS FOR MINIMAL IMPACT ON VIRAL KINETICS
EXOGENOUS GENE EXPRESSION IN THERAPEUTIC ADENOVIRUS FOR MINIMAL IMPACT ON VIRAL KINETICS
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机译：治疗性腺病毒的外源基因表达，对病毒动力学的影响最小
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摘要
A recombinant adenovirus genome comprising an exogenous open reading frame (ORF) and a self-cleaving peptide coding sequence is described. Optimal placement of exogenous genes for minimal impact on viral kinetics is further disclosed. Applications of the recombinant adenovirus therapy are also described.
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