INDICATOR STEM CELL LINE/LIVING ORGANISM (NON-HUMAN) AND A METHOD FOR DETECTION OF THE GENOTOXIC POTENTIAL OF AQUATIC SAMPLES OR AQUEOUS SOLUTIONS OF TEST COMPOUNDS

摘要

Indicator stem cell line/transgenic (non-human) living organism for non-destructive, self-signalizing visualization of nuclear structures, which allows the identification of nuclear and chromosome anomalies—including micronuclei—as consequence of exposure to genotoxic compounds, wherein the stem cell line is a transgenic stem cell line from a (non-human) animal with nuclei labelled with a fluorescent protein fused to a chromatin-associated protein and/or the living organism is a transgenic (non-human) living organism in which a cell lineage has nuclei labelled with a fluorescent protein fused to a chromatin-associated protein.