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COCHLEAR INNER HAIR CELL PROMOTERS AND USES THEREOF
COCHLEAR INNER HAIR CELL PROMOTERS AND USES THEREOF
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机译:耳蜗内毛细胞启动子及其用途
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摘要
The disclosure provides polynucleotides containing inner hair cell-specific promoters, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in inner hair cells. The polynucleotides described herein may be operably linked to a transgene, such as a transgene encoding a therapeutic protein, so as to promote inner hair cell-specific expression of the transgene. The polynucleotides described herein may be operably linked to a therapeutic transgene and used for the treatment of subjects having or at risk of developing hearing loss.
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