APPLICATION OF EARTHWORM PROTEIN PEPTIDE IN PREPARATION OF MEDICINE FOR PREVENTING AND/OR TREATING THROMBOTIC DISEASE

摘要

The present invention relates to application of an earthworm protein peptide in the preparation of a medicine for preventing and/or treating a thrombotic disease, which belongs to the technical field of prevention and treatment of cardiovascular and cerebrovascular diseases. The earthworm protein peptide is one or more members selected from a group consisting of Leu-Val-Thr-Leu-Gly-Asn-Glu, Leu-Leu-Ala-Pro-Pro, Leu-Leu-Pro-Ala-Pro and Thr-Val-Ala-Pro-Phe. The earthworm protein peptide provided by the present invention can significantly inhibit the thrombin activity, thus achieving the anticoagulant effect. In vivo, the earthworm protein peptide provided by the present invention has a significant inhibitory effect on carrageenan-induced rat tail thrombosis; and in vitro and in vivo studies of rats with thrombus, the earthworm protein peptide provided by the present invention shows good anticoagulant effects. The earthworm protein peptide provided by the present invention has effects of thrombosis inhibition, thrombolysis, anticoagulation and fibrinolysis promotion, and can effectively prevent and treat thrombotic disease.