COMPOSITION, COMPRISING SALVIA PLEBEIA R. BR. EXTRACT AS ACTIVE INGREDIENT, FOR INHIBITING TUMOR GROWTH

摘要

The present invention relates to a composition, comprising a Salvia plebeia R. Br. extract as an active ingredient, for inhibiting tumor growth. A Salvia plebeia R. Br. extract was found to bind to PD-L1 present on cancer cell surfaces to block the interaction of cancer cells with PD-1 on the surface of immune T cells, thereby activating T cells to show a suppressive effect on tumor growth. When T cells were cocultured with colorectal cancer, breast cancer, or lung cancer cells, an effect of killing cancer cells was found to be improved in a Salvia plebeia R. Br. extract-treated group.