Targeted interventions aimed at reducing the level of circulating succinate in a subject and kits and methods for determining the effectiveness of said interventions.

摘要

The present invention measures the ratio of succinate-producing bacteria to succinate-consuming bacteria in a subject-derived stool sample, particularly the (Prevotellaceae + Vellonellaceae) / (Odoribacteriae + Clostridiace) ratio, or the level of succinate in a subject-derived biofluid sample. Regarding kits suitable for measurement. The present invention also relates to a method for determining whether a targeted intervention aimed at reducing the level of circulating succinate in a subject was effective. Finally, the present invention relates to targeted interventions for use in the prevention and / or treatment of diseases associated with high levels of circulatory succinate in patients.