A multispecific antigen-binding molecule that has the function of substituting the function of blood coagulation factor VIII.

摘要

PROBLEM TO BE SOLVED: To provide a multispecific antigen-binding molecule having a function of substituting the function of blood coagulation factor VIII. SOLUTION: It specifically binds to both blood coagulation factor IX / activated blood coagulation factor IX and blood coagulation factor X, and has a coagulation factor function of blood coagulation factor IX, that is, activated blood coagulation factor IX. Various bispecific antibodies having a function of substituting the function of promoting the activation of blood coagulation factor IX were prepared, and among these antibodies, the activity of substituting the function of blood coagulation factor IX found was found. Highly multispecific antigen-binding molecule. [Selection diagram] None