Pharmaceutical composition for treating ototoxicity hearing loss by additional effect of cisplatin comprising alpha-lipoic acid

摘要

The present invention relates to a pharmaceutical composition for treating ototoxic hearing loss by cisplatin containing alpha-lipoic acid as an active ingredient or a health functional food for improvement, wherein alpha-lipoic acid (ALA) is used in cisplatin. Reduces hearing loss during hearing test for mice with ototoxic hearing loss caused by ototoxicity, and prevents damage to auditory hair cells and spiral ganglion cells during morphological observation by extracting the inner ear of the mouse, and Bax gene or protein in auditory hair cells By reducing the expression and increasing the Bcl-2 gene or protein expression, the dysfunction of the mitochondria is improved, and the free radical ROS is reduced, so that the composition of the present invention can be effectively used for the treatment of ototoxicity.