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METHODS OF IMPROVING EXERCISE PERFORMANCE, SINGLE VENTRICULAR PERFORMANCE, AND MYOCARDIAL PERFORMANCE INDEX (MPI) IN SINGLE VENTRICLE HEART DISEASE, USING UDENAFIL COMPOSITIONS
METHODS OF IMPROVING EXERCISE PERFORMANCE, SINGLE VENTRICULAR PERFORMANCE, AND MYOCARDIAL PERFORMANCE INDEX (MPI) IN SINGLE VENTRICLE HEART DISEASE, USING UDENAFIL COMPOSITIONS
Various methods of treating single ventricle heart disease SVHD patients, including patients who have undergone Fontan surgery (Fontan patient), to improve exercise performance, single ventricular performance, cardiac output and myocardial performance index (MPI) in the SVHD patients, including the Fontan patients, using udenafil compositions. The methods of the present invention include administering an effective amount of udenafil or a pharmaceutically acceptable salt thereof to a SVHD patient, including a Fontan, to improve the ventricular performance of the SVHD patient's, including the Fontan patient's, single functioning ventricle. In addition, the methods of the present invention include administering an effective amount of udenafil or a pharmaceutically acceptable salt thereof to a SVHD patient, including a Fontan patient, to improve the SVHD patient's, including the Fontan patient's, MPI. IThe methods of the present invention further include administering an effective amount of udenafil or a pharmaceutically acceptable salt thereof to a SVHD patient, including a Fontan patient, to improve the SVHD patient's, including the Fontan patient's, cardiac output. The methods of the present invention further include administering an effective amount of udenafil or a pharmaceutically acceptable salt thereof to a SVHD patient, including a Fontan patient, who is at least 6 years old, to improve at least one or more or all of the following in the SVHD patient, including the Fontan patient: (a) ventricular performance of the SVHD patient's, including a Fontan patient's, single functioning ventricle as measured by MPI; (b) exercise capacity as measured by oxygen consumption at anaerobic threshold (VAT); (c) exercise capacity as measured by oxygen consumption at maximal effort or max VO2; (d) work rate at VAT; (e) VE/VCO2 at VAT; diastolic blood pressure at rest; and (g) oxygen saturation (%) at rest.
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