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Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors
Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors
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机译:可鳞可鳞可鳞状甲状腺蛋白拮抗剂,具有改善的血脑屏障渗透和保留血脑肿瘤
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摘要
Chemical compounds/compositions, methods of synthesis, and methods of use. The compounds/compositions are directed toward thyrointegrin antagonists conjugated to a polymer. The compounds/compositions further comprise an additional substituent also conjugated to the polymer. The compounds/compositions demonstrate increased uptake across the blood brain barrier along with increased retention therein and retention within tumor. The compounds/compositions may also include improved synthesis scalability, improved purity, improved aqueous solubility, and a solid product or intermediate. The compounds/compositions may demonstrate improved antiangiogenic effect and improved efficacy against conditions, particularly cancers, requiring blood brain barrier permeability, for example, glioblastoma (GBM).
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