AD (Alzheimer's disease), FTLD (frontotemporal lobar degeneration), ALS (amyotrophic lateral sclerosis), PD (Parkinson's disease) and DLB (Lewy body dementias) using the phosphorylation of MARCKS as an index detection

摘要

Providing a method for detecting neurodegenerative diseases selected from the group consisting of human AD (Alzheimer's disease), FTLD (frontotemporal lobar degeneration) and ALS (amyotrophic lateral sclerosis) with high sensitivity and high specificity. .. A method for detecting a neurodegenerative disease selected from the group consisting of human AD (Alzheimer's disease), FTLD (frontotemporal lobar degeneration) and ALS (muscle atrophic lateral sclerosis), including the following steps: (i) ) Step of measuring phosphorylated MARCKS protein and non-phosphorylated MARCKS protein at position 46 in the sample sample collected from the subject; (ii) It is expressed by the following formula from the measured values obtained in (i). Step to calculate DO value; and [Formula 1] [In the formula, "pSer46-MARCKS" indicates the amount of MARCKS protein phosphorylated at position 46, and "non-phosphorylated-MARCKS" indicates the amount of non-phosphorylated MARCKS protein. Indicates the amount] (iii) A method including a step of detecting a neurodegenerative disease using a DO value as an index.