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Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen
Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen
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机译:使用靶向高度特异性肿瘤细胞表面抗原的人抗体的肿瘤特异性有效载荷和免疫激活
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摘要
This invention provides antibodies directed against a highly specific and previously unrecognized marker for cancerous cells. In certain embodiments an isolated antibody or fragment thereof that specifically binds human placentally expressed ALPP and/or ALPPL2, but not ALPL and ALPI that are expressed outside the placenta is provided as well as immunoconjugates comprising such antibodies.
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