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Method for providing the information for prediction of lymph node metastasis of gastric cancer
Method for providing the information for prediction of lymph node metastasis of gastric cancer
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机译:提供胃癌淋巴结转移预测信息的方法
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摘要
The present invention relates to a method of providing information for predicting lymph node metastasis of gastric cancer, and in more detail, the maximum standard intake of primary cancer in F-18 FDG (fluoro-2-deoxyglucose) PET/CT (positron emission tomography/computed tomography) The present invention relates to a method of providing information for predicting lymph node metastasis of gastric cancer by combining the coefficient (T_SUVmax) and the maximum standard intake factor (N_SUVmax) of a lymph node with hematological information of a gastric cancer patient. In the present invention, the maximum standard intake coefficient (T_SUVmax) and the maximum standard intake coefficient (N_SUVmax) of the lymph nodes obtained from F-18 FDG PET/CT before surgery, and the tumor marker CA19-9 and albumin (Albumin) among hematologic indicators In this multivariate logistic regression analysis, it was confirmed that it was a statistically significant association factor in predicting lymph node metastasis. Finally, the area under the curve of the model made with the four parameters T_SUVmax, N_SUVmax, CA19-9, and Albumin; AUC) of 0.780 was confirmed to be the most suitable model for predicting lymph node metastasis of gastric cancer, and thus, information on whether or not lymph node metastasis of gastric cancer can be effectively provided using the above four parameters.
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机译:本发明涉及提供用于预测胃癌淋巴结转移的信息的方法,更详细地,F-18 FDG(Fluoro-2-脱氧葡萄糖)PET / CT(正电子发射断层扫描)中原发癌的最大标准摄入量/计算断层扫描)本发明涉及通过将淋巴结的系数(T_SUVMAX)和淋巴结的最大标准进气因子(N_SUVMAX)与胃癌患者的血液学信息组合来提供用于预测胃癌淋巴结转移的方法。在本发明中,从手术前的F-18 FDG PET / CT获得的淋巴结的最大标准进气系数(T_suvmax)和最大标准进气系数(N_SUVMAX),以及肿瘤标志物CA19-9和白蛋白(白蛋白)在这种多变量逻辑回归分析中的血液学指示剂中,证实它是预测淋巴结转移的统计学上显着的关联因子。最后,用四个参数T_suvmax,N_suvmax,Ca19-9和白蛋白制成的模型曲线下的区域; AUC)被证实是预测胃癌淋巴结转移的最合适的模型,因此可以使用上述四个参数有效地提供胃癌淋巴结转移的信息。
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