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Phosphorus-containing substituted bisphenols and compositions containing them and other substituted bisphenols
Phosphorus-containing substituted bisphenols and compositions containing them and other substituted bisphenols
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机译:含磷的取代双酚及包含它们和其他取代的双酚的组合物
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摘要
Novel monophosphoric acid esters of bisphenols of the formula FORM:1122244/C2/1 where X is hydrogen or halogen and Y is halogen, are prepared by treating the bisphenol with phosphoryl chloride and hydrolysing the cyclic phosphorochloridate obtained, through the cyclic phosphate, to the monophosphoric acid ester. The reaction is advantageously carried out in the presence of pyridine. The compounds and their physiologically acceptable salts are effective in the treatment of liver-fluke. 4,41 - Dibromo - 6,61 - dichloro - 0,01 -bisphenol is prepared by reacting 4,41-dibromo-0,01 -bisphenol with sulphuryl chloride.ALSO:Antiparasitic compositions useful in the treatment of liver fluke contain an effective amount of a bisphenol of formula: FORM:1122244/A5-A6/1 where X represents hydrogen or halogen and Y represents halogen, or a physiologically acceptable salt thereof, or a monophosphoric acid ester of the bisphenol or a physiologically acceptable salt thereof. Alkali metal salts are particularly useful and suitable carriers are talc, magnesium stearate, amylum, lactose and physiologically acceptable solvents. The compositions may be administered as tablets, pills, capsules or potions.
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