process for the production of the new d seryl - l - tyrosyl - l - seryl - l - methionyl - l - glutamyl - (or l - glutaminyl) - l - histidyl - l - phenylalanyl - l - arginyl - l - tryptophyl - glycyl - l - lysyl - l - prolyl - l - valyl - glycyl - l - lysyl - l - lysyl - l - lysyl - l - lysine or its amids

摘要

Preparation of D-serlys17.18 beta-1-18 corticotropine lys18-amide (I) in which arginine in positions 17 and 18 of D-ser beta1-19 corticotropine are replaced by lysine; and also the corresponding derivative in which the glutamyl residue is replaced by glutamine. D-seryl, L-tyrosyl, L-seryl, L-methionyl, L-glutamyl, L-histidyl, L-phenylalanyl, L-arginyl, L-tryptophyl glycyl, L-lysyl, L-prolyl, L-valyl glycyl, L-lysyl, L-lysyl, L-lysyl, L-lysine The polypeptide is prepared by linking small groups of amino acids in which the amino acids are masked by t-butoxy-carbonyl groups and the carboxy groups by a t-butyl ester group, and then combining the larger units. Strong adrenocorticotropic activity.