N{11 {11 {11 {11 {11 {11 , N{11 {11 {11 {11 {11 {11 -DI-TERT. BUTYLOXYCARBONYL-INSULIN AND PROCESS FOR ITS MANUFACTURE

摘要

N (A1), N (B29)-di-tert. butyloxycarbonyl insulin, useful as a hypoglycemic agent. A method for its preparation by reacting insulin, in a mixture of an N,N'-dialkylcarboxylic acid amide having a total of from three to six carbon atoms and an aqueous buffer solution having a pH between 8.0 and 9.0, with a 20 to 75 fold molar excess of tert. butyloxycarbonyl azide at 20 DEG to 50 DEG C.