process for the production of trialkylphosphingoldkomplex compounds 1 - b - d - glukopyranosiden or 1 - thiometon - b - d - glukopyranosiden or 1 - b - d - glukopyranosen thiometon

摘要

1,270,776. 1-#-D-Glucopyranosides and trialkyl phosphinegold complexes thereof. SMITH KLINE & FRENCH LABORATORIES. 26 Oct., 1970 [28 Oct., 1969], No. 50726/70. Headings C2C and C2P. The invention comprises compounds of the Formula I and Formula II where Z is -O- or -NH-, R is acetyl, or when Z is -O-, R may also be H, R 1 is C 1-4 alkyl, A is C 2-5 alkylene and Y is O or S, which may be prepared by reacting an alkali metal salt of a thioalkyl-1-#-D-glucopyranoside or of a 1-thio-#-D-glucopyranoside with a trialkyl phosphinegold halide. The compounds of Formulµ I and II have antiarthritic activity and may be employed as pharmaceutical agents in combination with conventional carriers. Trialkylphosphinegold halides in which the alkyl groups contain 1-4 carbon atoms may be prepared by treating a solution of thiodiglycol in an organic solvent with an aqueous solution of gold acid chloride trihydrate at -10‹ to - 5‹ C. and reacting the product with a trialkylphosphine. S - Acetyl - 2SP1 /SP. thioethyl 2,3,4,6 - tetra - O- acetyl - # - D - glucopyranoside, S - acetyl - 2SP1/SP- thioethyl 1 - thio - 2,3,4,6 - tetra - O acetyl - #- D - glucopyranoside, S - acetyl - 2SP1/SP - thiopropyl 1 - thio - 2,3,4,6 - tetra - O - acetyl - # - D - glucopyranoside and S - acetyl - 1SP1/SP - methyl - 2SP1/SP - thiopropyl 1 - thio - 2,3,4,6 - tetra - O acetyl - # - D- glucopyranoside may be prepared by reacting the corresponding 2SP1/SP-haloalkyl #-D glucopyranoside with potassium thioacetate. 2SP1/SP - Bromopropyl 1 - thio - 2,3,4,6 - tetra - O- acetyl - # - D - glucopyranoside and 1SP1/SP methyl- 21 - bromopropyl 1 - thio - 2,3,4,6 - tetra - O- acetyl - # - D - glucopyranoside may be prepared by reacting S-acetyl 1-thio-2,3,4,6-O- acetyl-#-D-glucopyranose with bromine, removing the excess bromine, and reacting the product with propylene or trans-2-butene.