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the afgeleide de georganiseerde verbindingen bleomycine professional research
the afgeleide de georganiseerde verbindingen bleomycine professional research
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机译:有组织的化合物博来霉素的衍生物专业研究
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1435662 Bleomycin derivatives PHILIPS GLOEILAMPENFABRIEKEN NV 20 March 1974 [22 March 1973] 12332/74 Heading C2C Novel bleomycin derivatives consisting of bleomycin coupled via an amido group to an amino acid, the amino acid being marked by a radio-active isotope, are prepared (a) by reacting an amino acid or ester thereof, marked with a radio-active isotope, with bleomycin in an aqueous medium in the presence of a carbodiimide or glutare dialdehyde or (b) by iodizing bleomycin, linked via an amido group to an amino acid containing a phenolic group, with the iodine isotope SP123/SPI, SP125/SPI or SP131/SPI so that at least one atom of the isotope is introduced into the phenyl nucleus of the phenolic group. Injectable compositions for diagnostic examination of tumours comprise a bleomycin derivative as defined above and a suitable liquid carrier.
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