CERTAIN 4 - AMINO - 2-(5-NITRO-2-THIENYL) QUINAZOLINES AND THE INTERMEDIATE 4 - CHLORO-(5 - NITRO-2-THIENYL)QUINAZOLINES THEREFOR

摘要

1292418 Nitrothiophene derivatives NORWICH PHARMACAL CO 19 April 1971 [26 Jan 1970] 27351/72. Divided out of 1292417 Heading C2C Novel compounds of Formula I (in which R is H or Cl), are prepared by reacting 5 - nitro - 2 - thiophene - carboxaldehyde with 2 - aminobenzamide or 2 - amino - 5 - chlorobenzamide to give 1,2 - dihydro - 2 - (5- nitro - 2 - thienyl) quinazolin - 4(3H) - one or 6 - chloro - 1,2 - dihydro - 2 - (5 - nitro - 2- thienyl) quinazolin - 4(3H) - one, heating this with p-benzoquinone to give 2-(5-nitro-2- thienyl) quinazolin - 4(3H)one or 6 - chloro - 2- (5 - nitro - 2 - thienyl) quinazolin - 4(3H) - one and reacting this with phosphorus oxychloride and phosphorus pentachloride.